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Low-grade gliomas | Treatment | Chemotherapy | Temozolomide




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Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Sargos P, Taphoorn MJB, Vauleon E, Philips C, Kros JM, Bady P, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Jacob J, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Balana C, Azevedo ALS, Clement PM, Berghoff A, Tzuk-Shina T, Weller M, Nordal RA, Rees J, Lacombe DA, Mason WP, Stupp R.
Temozolomide Versus Radiotherapy as First-Line Therapy for Low-Grade Glioma: Mature Results of a Randomized Phase III Trial (EORTC 22033-26033/NCIC-CTG/TROG/MRC-CTU).
J Clin Oncol. 2026 Jul 2:JCO2502735. doi: 10.1200/JCO-25-02735. PMID: 42391581. Trial registration ID: EORTC 22033-26033˰ ˍ






Marciscano AE, Shih HA.
Biology Over Monotherapy: Mature Results From European Organisation For Research and Treatment of Cancer 22033-26033 Reaffirm Molecular Stratification, Not Treatment Sequence, Defines Prognosis in Low-Grade Glioma.
J Clin Oncol. 2026 Jul 2:JCO2600771. doi: 10.1200/JCO-26-00771. PMID: 42391595. ˍ