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Medulloblastoma | Treatment | Targeted therapy | Vismodegib

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Erker C, Mynarek M, Simbozel M, Craig BT, Harrod VL, Cappellano AM, Cohen KJ, Lopez VS, Morales-La Madrid A, Cacciotti C, Baroni L, Salloum R, Margol AS, Michaiel G, Aguilera D, Mazewski CM, Kline CN, Finlay JL, Abdelbaki MS, Murray JC, Dorris K, Crooks B, Ginn KF, Amayiri N, Tippelt S, Fleischhack G, Tonn S, Gerber NU, Lassaletta A, Hansford JR, Khan S, Gilheeney SW, Hoffman LM, Zapotocky M, Larouche V, Shah S, Ramaswamy V, Gajjar A, Perreault S, Mueller S, Hukin J, Cheng S, Wang ZJ, Matheson K, Bailey S, Bouffet E, Clifford SC, Robinson G, Dufour C, Rutkowski S, Lafay-Cousin L.
Salvage therapies for first relapse of SHH medulloblastoma in early childhood.
Neuro Oncol. 2025 Apr 4:noaf092. doi: 10.1093/neuonc/noaf092. PMID: 40186336. Observational study. ˍ

Bosio A, Maccari M, Padovan M, Caccese M, Bolshinsky M, Galiano A, Cavallin F, Bellu L, Pasqualetti F, Parisi A, Librizzi G, Pintacuda G, Salvalaggio A, Zoccarato M, Ius T, Volpin F, Denaro L, Lonardi S, Lombardi G.
Real-world management and long-term outcomes in adolescent, young adult, and adult medulloblastoma: Experience from a monocentric series with multimodal and targeted approaches.
Neurooncol Pract. 2025 Oct 24;13(2):385-393. doi: 10.1093/nop/npaf110. PMID: 42111030. ˍ ˍ

Abdi S, Poikonen-Saksela P, Halonen P, Tynninen O, Reardon DA, Hernberg M. A
10-year-long ongoing complete response to vismodegib as first-line treatment in adult metastatic medulloblastoma.
Acta Oncol. 2026 May 11;65:412-415. doi: 10.2340/1651-226X.2026.45543. PMID: 42109078. ˍ