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Home > Publications > Topics > Pediatric CNS tumors > Treatment > Clinical trials > CAR-T-cells
Lin
FY, Stuckert A, Tat C, White M, Ruggieri L, Zhang H, Mehta B,
Lapteva N, Mei Z, Major A, Thakkar S, Shum T, Parikh K, Wu MF,
Lindsay HB, Scherer L, Shekar M, Baxter P, Wang T, Grilley B,
Moeller K, Hicks J, Roy A, Anastas J, Malbari F, Aldave G,
Chintagumpala M, Blaney S, Parsons DW, Brenner MK, Heslop HE,
Rooney CM, Omer B.
Phase
I Trial of GD2.CART Cells Augmented With Constitutive
Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS
Tumors.
J
Clin Oncol.
2024 May 21:JCO2302019. doi:
10.1200/JCO.23.02019. PMID:
38771986. Interventional study. ˍ
Gust J, Cole BL, Ronsley R, Wilson AL, Seidel K, Wendler J,
Pattabhi S, Brown C, Rawlings-Rhea SD, Shtanukhina N, Browd SR,
Hauptman JS, Lee A, Ojemann JG, Crotty EE, Leary SES, Perez FA,
Wright JN, Albert CM, Pinto N, Gardner RA, Vitanza NA, Jensen MC,
Park JR.
Locoregional Infusion of
EGFR806-CAR T Cells for Recurrent or Refractory Pediatric CNS
Tumors: Results of the Completed BrainChild02 Phase 1 Clinical
Trial.
Neuro
Oncol. 2025 Mar 12:noaf064. doi:
10.1093/neuonc/noaf064. PMID:
40070357. Interventional study˰
ˍ
Ronsley R, Huang W, Rohlf E, Seidel K, Brown C, Beebe A,
Rawlings-Rhea SD, Lindgren C, Sad T, Crotty EE, Leary SES, Thomsen
A, Beckstrom AR, Holtzclaw SL, Hoeppner C, Hurst D, MacQuivey M,
Goldstein HE, Browd SR, Hauptman JS, Lee A, Ojemann JG, Wright JN,
Albert CM, Pinto N, Gustafson JA, Ho O, Pattabhi S, Summers C,
Annesley C, Wendler JN, Gust J, Gardner RA, Park JR, Jensen MC,
Vitanza NA.
Intracerebroventricular
B7-H3-targeting CAR T cells for non-pontine DMG and
recurrent/refractory pediatric CNS tumors: a phase 1 trial.
Neuro
Oncol. 2026 Jul 25:noag171. doi:
10.1093/neuonc/noag171. PMID:
42503899. Trial
registration ID: NCT04185038˰
ˍ