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Adult-type Diffuse Gliomas | Treatment | Immunotherapy | Viruses

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Ning W, Qian X, Dunmall LC, Liu F, Guo Y, Li S, Song D, Liu D, Ma L, Qu Y, Wang H, Gu C, Zhang M, Wang Y, Wang S, Zhang H.
Non-secreting IL12 expressing oncolytic adenovirus Ad-TD-nsIL12 in recurrent high-grade glioma: a phase I trial.
Nat Commun. 2024 Nov 8;15(1):9299. doi: 10.1038/s41467-024-53041-7. PMID: 39516192. Interventional study. ˍ

Erickson NJ, Stavarache M, Ibrahim T, Kaplitt MG, Markert JM.
Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery.
World Neurosurg. 2024 Dec 20:123595. doi: 10.1016/j.wneu.2024.123595. PMID: 39710201. Review˰ ˍ

Zeng W, Wang P, Fang S, Ge S, Jia W, Peng S, Wang M, Qin X, Zhang W, Gao J, Su X, Yuan G, Wu J, Liu Y, Wang Y, Lu H, Mu R, Wu F, Chang Q, Jin G, Meng F, Zhang J, Liu F.
ON-01, an engineered recombinant oncolytic herpes simplex virus type-1, in recurrent glioma: a single-arm, phase 1/2 study.
Neuro Oncol. 2026 Jan 12:noag005. doi: 10.1093/neuonc/noag005. PMID: 41527280. Interventional study. ˍ