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Gliomas | Etiopathogenesis | Recurrence

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Marino S, Menna G, Doglietto F, Quaranta D, Chiesa S, Gaudino S, Russo R, Marziali G, Galeazzi M, D'Alessandris QG, Lauretti L, Mattogno PP, Di Bonaventura R, Caraglia N, Di Maio L, Olivi A, Della Pepa GM.
A white matter-centered approach to investigate recurrence pathways in high-grade gliomas: a single-center retrospective study.
J Neurooncol. 2025 Jun 3;174(1):177-190. doi: 10.1007/s11060-025-05050-9. PMID: 40459831. Observational study. ˍ

... Our analysis, focused on exploring the spatial aspects of recurrence in relation to white matter anatomy, suggests that HGG recurrence patterns are strongly influenced by anatomical location and white matter architecture. Certain anatomical areas show a predisposition toward specific recurrence patterns. Recognizing these spatial dynamics may guide more precise surgical strategies, radiotherapy targeting, and recurrence risk assessment.