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High-grade gliomas | Treatment | Radiotherapy | Margins

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Niitsu H, Fukumitsu N, Tanaka K, Mizumoto M, Nakai K, Matsuda M, Ishikawa E, Hatano K, Hashimoto T, Kamizawa S, Sakurai H.
Methyl-¹¹C-L-methionine positron emission tomography for radiotherapy planning for recurrent malignant glioma.
Ann Nucl Med. 2024 Feb 14. doi: 10.1007/s12149-024-01901-z. PMID: 38356008. Observational study. ˍ

Qiu Y, Li Y, Cuihong J, Wu X, Liu W, Fan C, Ye X, He L, Xiao S, Zhao Q, Wu W, Chen K, Tan C, Li Y, Wang H, Liu F.
Toxicity and Efficacy of Different Target Volume Delineations of Radiotherapy Based on the Updated RTOG/NRG and EORTC Guidelines in Patients with Grade 3-4 Glioma: A Randomized Controlled Clinical Trial.
Int J Radiat Oncol Biol Phys. 2024 Nov 28:S0360-3016(24)03668-X. doi: 10.1016/j.ijrobp.2024.11.094. PMID: 39615657. Interventional study˰ ˍ

Sun F, Zhu Y, Gan G, Xu Y, Xu X.
Therapeutic and prognostic impact of target volume delineation in postoperative radiotherapy for high-grade glioma patients with subventricular zone involvement.
Radiat Oncol. 2025 Feb 19;20(1):24. doi: 10.1186/s13014-025-02601-2. PMID: 39972483. Observational study. ˍ

Zhong L, Zhou P, Chen L, Chen D, Wen L, Diao X, Zhang A, Gao Y, Chen G, Li X, Huang S, Niu K, Pei Y, Liu G, Lv S, Li G. Modified Target Delineation and Moderately Hypofractionated Radiotherapy for High-Grade Glioma: A Randomized Clinical Trial. JAMA Netw Open. 2025 Jul 1;8(7):e2523053. doi: 10.1001/jamanetworkopen.2025.23053. PMID: 40705330. Interventional study. ˍ ChiCTR.org.cn ID: ChiCTR1800014396.

Anvari K, Javadinia SA, Fazilatpanah D, Esmaily H, Aledavood SA, Shahidsales S, Ganjeifar B, Dayani M, Rabiei P.
Comparing the Recurrence Patterns of Reduced-Margins vs. RTOG-Protocol in Adjuvant Chemoradiation of High-Grade Gliomas: A Multicenter, Open-Label, Randomized Controlled Trial.
Asian Pac J Cancer Prev. 2026 Jun 18;27(6):2005-2013. doi: 10.31557/APJCP.2026.27.6.2005. PMID: 42345146. Trial registration ID: IRCT20210215050367N1. ˍ