Topics


Metastases to the CNS | Treatment | Clinical trials | Breast Cancer






Home > Publications > Topics > Metastases to the CNS > Treatment > Clinical trials > Breast Cancer






Bartsch R, Marhold M, Garde-Noguera J, Gion M, Ruiz-Borrego M, Greil R, Valero M, Llombart-Cussac A, García-Mosquera JJ, Arumi M, Cortés J, Campolier M, Guerrero JA, Slebe F, Martínez-García E, Jiménez-Cortegana C, Vaz-Batista M, Oberndorfer F, Furtner J, Fuereder T, Berghoff AS, Preusser M.
Patritumab deruxtecan (HER3-DXd) in patients with active brain metastases of breast cancer (TUXEDO-3): a multicentre, single-arm, phase 2 trial.
Lancet Oncol. 2025 Oct 27;26(11):1467-1478. doi: 10.1016/S1470-2045(25)00470-X. PMID: 41167215. Interventional study˰




Li T, Zhou T, Wang B, Tao Z, Zhao M, Wang L, Jin J, Zhao Y, Gong C, Cao J, Miao H, Peng W, Wang J, Jin M, Hu X, Zhang J.
Phase II Clinical Study of Adebrelimab and Bevacizumab Combined With Cisplatin/Carboplatin in Patients With Triple-Negative Breast Cancer With Brain Metastases (ABC Study).
J Clin Oncol. 2026 Mar 4:JCO2502021. doi: 10.1200/JCO-25-02021. PMID: 41779972. Clinical trials.gov ID: NCT04303988. ˍ




Giordano A, Graham N, Aizer AA, Tayob N, Pereslete AM, Schoenfeld JD, Leone JP, Davis R, Erick TK, Mayer EL, Winer EP, Krop I, Tolaney SM, Lin NU.
A phase II study of atezolizumab in combination with stereotactic radiation for patients with triple-negative breast cancer and brain metastasis.
Breast Cancer Res Treat. 2026 Mar 7;216(2):24. doi: 10.1007/s10549-026-07932-6. PMID: 41793510. Clinicaltrials.gov ID: NCT03483012. ˍ