Neuro-Oncology Reviews




Volume 27 Number 35
20 December 2025




Home > Publications > Neuro-Oncology Reviews > Volume 27, Year 2025 > Number 35, 20 December






Drappatz J, Mantica M.
Treatment strategies and innovation for recurrent high-grade glioma.
J Neurooncol. 2025 Dec 11;176(1):118. doi: 10.1007/s11060-025-05323-3. PMID: 41381983. Review˰ ˍ




Drapkin AJ.
On the question of prognosis in cystic gliomas.
World Neurosurg. 2025 Dec 11:124714. doi: 10.1016/j.wneu.2025.124714. PMID: 41390081. Perspective. ˍ




Karsonovich T, Gasalberti DP, Rayi A.
Low-Grade Gliomas.
StatPearls Publishing, Treasure Island (FL), 2025 Dec 13. PMID: 32809503. Bookshelf ID: NBK560668. Book. ˍ




McKerill E, Tan JK, Rao CK, Linares CA, Banerjee S, Rabbani RD, Adeleke S, Ghose A, Boussios S.
Efficacy of ketogenic metabolic therapy as an adjuvant to the current standard of care in the treatment of glioblastoma: A systematic review of clinical trials.
Med Oncol. 2025 Dec 11;43(1):49. doi: 10.1007/s12032-025-03165-7. PMID: 41379280. Review. ˍ




Ehret F, Rogers CL, Fontanesi J, Wilson GD, Chitti BS, Starner J, Sidiqi B, Goenka A, Schulder M, Bruynzeel AME, Verhoeff JJC, MacDonagh AC, Park HI, Shih HA, Kleinberg L.
Radiation Therapy for Non-Malignant Central Nervous System Tumors, Disorders, and Illnesses - Current Applications and Future Directions.
Semin Radiat Oncol. 2025 Dec 12;36:77-94. doi: 10.1016/j.semradonc.2025.08.005. PMID: 41391900. Review. ˍ




Scagliotti E, Capetti B, Conti L, Fiore G, Fanizzi C, Bertani G, Pravettoni G, Locatelli M.
Effects of proton therapy on cognition in adults with brain tumors: a systematic review.
J Neurooncol. 2025 Dec 12;176(1):121. doi: 10.1007/s11060-025-05371-9. PMID: 41385035. Review˰ ˍ




Jia L, Chen Y, Li H, Zhao K, Ge S, Wang C, Zhao J, Li F, Zhang L, Yao A.
The glymphatic system in neurodegenerative diseases and brain tumors: mechanistic insights, biomarker advances, and therapeutic opportunities.
Acta Neuropathol Commun. 2025 Dec 13. doi: 10.1186/s40478-025-02203-9. PMID: 41390476. Review. ˍ




Love CA, Figg JW, Engelbart M, West I, Flores C.
Radial glial cells and glioblastoma: how developmental neurobiology can inform our understanding of brain cancer initiation, treatment resistance, and resilience.
Transl Oncol. 2025 Dec 13;64:102645. doi: 10.1016/j.tranon.2025.102645. PMID: 41391380. Review. ˍ




Boffelli L, Fimiani C, Núñez NG, Kienzler JC.
Synergy of radiotherapy, focused ultrasound, and immunotherapy in the treatment of brain metastases.
J Neurooncol. 2025 Dec 15;176(1):124. doi: 10.1007/s11060-025-05379-1. PMID: 41396538. Review. ˍ




Sadhasivam S, Velpula S, Prasanna L, Arora RK, Menon G, Nair SN.
Impact of awake mapping on extent of resection and neurological outcomes of Low-grade gliomas: a systematic review and Meta-analysis.
Neurosurg Rev. 2025 Dec 16;49(1):74. doi: 10.1007/s10143-025-03998-w. PMID: 41398134. Review; Meta-analysis˰ ˍ




Pang C, Wang Y.
The Immunosuppressive Microenvironment of Glioblastoma: Mechanisms, Clinical Challenges and Future Directions.
Immunology. 2025 Dec 19. doi: 10.1111/imm.70087. PMID: 41414954. Review. ˍ








Galldiks N.
Influence of corticosteroids on contrast enhancement in patients with untreated glioblastoma.
Neuro Oncol. 2025 Sep 11:noaf207. doi: 10.1093/neuonc/noaf207. PMID: 41384841. Editorial˰ ˍ




Amjad A, Ali MR, Khalid M, Segawa F.
Liquid biopsies for early detection of gliomas: are we near a breakthrough?
Ann Med Surg (Lond). 2025 Sep 30;87(12):7862-7863. doi: 10.1097/MS9.0000000000003987. PMID: 41377322. Editorial. ˍ




Zafar S, Furqan M, Binte Rahim S, Haider MU.
Dordaviprone in H3K27M-mutant diffuse midline glioma: an editorial on emerging targeted therapy.
Ann Med Surg (Lond). 2025 Oct 13;87(12):7886-7888. doi: 10.1097/MS9.0000000000004079. PMID: 41377309. Editorial. ˍ




Tague C, Ekouo J, Makeda D, Yokolo H, Onesime J, Banga S, Kashafali A, Taj J, Akilimali A.
Toward cancer immunoprevention: what are the prospects for therapeutic vaccines?
Ann Med Surg (Lond). 2025 Oct 30;87(12):7926-7927. doi: 10.1097/MS9.0000000000004234. PMID: 41377366. Editorial. ˍ




Bria J, Filardo A, Di Vito A, Della Torre A, Lavano A, Coscarella I, Chiarella E, Procopio E, Egiziano MT, Longo P, La Torre D.
Recurrent Limitations of CAR-T Therapy in Gliomas: Evidence from Preclinical and Phase I Clinical Studies.
Int J Mol Sci. 2025 Nov 26;26(23):11435. doi: 10.3390/ijms262311435. PMID: 41373591. Review. ˍ




Fanuzzi M, Zheng S, Horbinski CM, Shaaban MA, Congivaram H, Du R, Tripathi S, Hurley L, Kumthekar P, Ahmed A, Brat DJ, Lesniak MS, Heimberger AB.
Targeting Survivin: Now I Become Death, the Destroyer of Cells.
Int J Mol Sci. 2025 Nov 26;26(23):11417. doi: 10.3390/ijms262311417. PMID: 41373575. Review. ˍ




Stathopoulos A, Glorieux P, Rokas EM, Savelkoul HFJ.
Combined Tumor Cell and Lysate-Based Vaccines for Immunotherapy of Primary and Recurrent Glioblastoma (GBM).
Cancers (Basel). 2025 Nov 26;17(23):3772. doi: 10.3390/cancers17233772. PMID: 41374974. Review. ˍ




Zoi V, Galani V, Sioka C, Alexiou GA, Kyritsis AP.
Immunotherapy for Glioblastoma: A Focus on PD-1/PD-L1 Inhibitors.
Cancers (Basel). 2025 Nov 26;17(23):3777. doi: 10.3390/cancers17233777. PMID: 41374979. Review. ˍ




Tleubergenov MA, Zhamoldin DK, Baymukhanov DS, Omarova AS, Ryskeldiyev NA, Doskaliyev A, Ukybassova TM, Akshulakov S.
Brain Tumors in Pregnancy: A Review of Pathophysiology, Clinical Management, and Ethical Dilemmas.
Cancers (Basel). 2025 Nov 30;17(23):3854. doi: 10.3390/cancers17233854. PMID: 41375054. Review. ˍ




Bao Y, Chen Z, Su Y, Guo T, Du H, Jia X.
From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS.
Front Immunol. 2025 Dec 1;16:1682030. doi: 10.3389/fimmu.2025.1682030. PMID: 41403936. Review. ˍ




Tang E, Chen JY.
Shaping the glioblastoma microenvironment to enhance CAR-NK immunotherapy.
Front Immunol. 2025 Dec 1;16:1681966. doi: 10.3389/fimmu.2025.1681966. PMID: 41403931. Review. ˍ




Duran G, Pichardo-Rojas D, Ali AH, Passias P, Downes A, Ray WZ, Zipfel GJ, Shakir HJ, Bauer A, Jea A, Dunn IF, Zuccato JA, Graffeo CS, Janjua MB.
Comparing Isocitrate Dehydrogenase Inhibitors with Procarbazine, Lomustine, and Vincristine Chemotherapy for Oligodendrogliomas.
Cancers (Basel). 2025 Dec 4;17(23):3880. doi: 10.3390/cancers17233880. PMID: 41375081. Review. ˍ




Bayona C, Ranđelović T, Ochoa I.
Tumor Microenvironment in Glioblastoma: The Central Role of the Hypoxic-Necrotic Core.
Cancer Lett. 2025 Dec 9:218216. doi: 10.1016/j.canlet.2025.218216. PMID: 41380902. Review. ˍ




Preetam S, Rabbee MF, Mishra R, Thapliyal S, Deshwal R, Rustagi S, Dashmana A, Govindarajan RK, Malik S.
Targeting brain tumours with precision: advances in magnetic nanoparticle therapy.
Nanoscale Adv. 2025 Dec 9. doi: 10.1039/d5na01046b. PMID: 41404476. Review. ˍ




Wang J, Zhang Y, Kang Z, Li S, Zhang R, Huang M, Wang C, Fan Y, Liu X, Chen Y, Han T, Wang Y, Li W.
Bidirectional Causal Effect Between Gut Microbiota and Glioma Risk: A Systematic Review-Based Mendelian Randomization and Immune-Mediated Effect Analysis.
Cancer Innov. 2025 Dec 9;4(6):e70039. doi: 10.1002/cai2.70039. PMID: 41384027. Review. ˍ




Sarfraz Z, Ranjan T, Mustafayev FNA, Jaramillo M, Odia Y, Venur VA, Ahluwalia MS.
Emerging therapies for glioblastoma.
J Neurooncol. 2025 Dec 10;176(1):116. doi: 10.1007/s11060-025-05248-x. PMID: 41372729. Review˰ ˍ




Zam A, Rouatbi N, Walters AA, Al-Jamal KT.
Overcoming barriers and shaping the future: Challenges and innovations in nucleic acid therapies for Glioblastoma.
Adv Drug Deliv Rev. 2025 Dec 10;229:115759. doi: 10.1016/j.addr.2025.115759. PMID: 41386501. Review. ˍ